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Panalean Review

by Josephine Mary (2019-02-06)

In the last 10 years, sale of Forskolin as a diet and weight loss supplement has sky-rocketed. Panalean As with any diet supplement, the pros and cons have been vigorously debated. Detractors have criticized it for the absence of strong scientific data to support its claims to aid weight loss. But closer examination shows the data in support of its claims to aid weight loss actually to be quite strong. Let's take a closer look:WHAT IS IT? Forskolin is a substance found in the herb Coleus forskohlii. Coleus is a type of mint that grows wild in India, Thailand, Sri Lanka and Nepal. In Ayurevedic medicine, Coleus had been used for centuries to treat skin conditions, breathing disorders like asthma and bronchitis, insomnia, epilepsy, and angina. In the 1970's, the drug company Hoechst Pharmaceuticals worked with the Indian Central Drug Research Institute to examine the properties of this herb. They discovered that its medical benefits were due to the substance Forskolin.WHAT DOES IT DO? Basically, Forskolin increases the activity of an enzyme in our bodies (adenylate cyclase) that, in turn, increases levels of intracellular cAMP . cAMP is a "messenger" molecule that our cells release when they come into contact with factors like hormones or neurotransmitters (such as epinephrine, growth hormone, and serotonin) that cannot by themselves cross the cell layer and enter the cell. The messenger cAMP helps them cross into the cell and thus helps the cells perform basic biological functions. When it activates cAMP, Forskolin helps stimulate lipodysis, or the breakdown of stored fat. From this comes its reputation as an aid to weight loss, particularly helpful to obese individuals who often have lower than normal levels of cAMP. Studies routinely show that higher cAMP levels promote fat burning.